NCCN Guidelines® Insights: Colorectal Cancer Screening, Version 1.2024

The NCCN Guidelines for Colorectal Cancer (CRC) Screening describe various colorectal screening modalities as well as recommended screening schedules for patients at average or increased risk of developing sporadic CRC. They are intended to aid physicians with clinical decision-making regarding CRC screening for patients without defined genetic syndromes. These NCCN Guidelines Insights focus on select recent updates to the NCCN Guidelines, including a section on primary and secondary CRC prevention, and provide context for the panel’s recommendations regarding the age at which to initiate screening in average-risk individuals and those with increased risk based on personal history of childhood, adolescent, and young adult cancer.

Authors

Reid M Ness ¹, Xavier Llor ², Mohammad Ali Abbass ³, Shrinivas Bishu ⁴, Christopher T Chen ⁵, Gregory Cooper ⁶, Dayna S Early ⁷, Mark Friedman ⁸, David Fudman ⁹, Francis M Giardiello ¹⁰, Kathryn Glaser ¹¹, Surya Gurudu ¹², Michael Hall ¹³, Lyen C Huang ¹⁴, Rachel Issaka ¹⁵, Bryson Katona ¹⁶, Trilokesh Kidambi ¹⁷, Audrey J Lazenby ¹⁸, Jennifer Maratt ¹⁹, Arnold J Markowitz ²⁰, Joseph Marsano ²¹, Folasade P May ²², Robert J Mayer ²³, Kinga Olortegui ²⁴, Swati Patel ²⁵, Shajan Peter ²⁶, Laura D Porter ²⁷, Mehnaz Shafi ²⁸, Peter P Stanich ²⁹, Jonathan Terdiman ³⁰, Peter Vu ³¹, Jennifer M Weiss ³², Elizabeth Wood ³³, Carly J Cassara ³⁴, Vaishnavi Sambandam ³⁴

Affiliations

¹Vanderbilt-Ingram Cancer Center.

²Yale Cancer Center/Smilow Cancer Hospital.

³Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

⁴University of Michigan Rogel Cancer Center.

⁵Stanford Cancer Institute.

⁶Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute.

⁷Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine.

⁸Moffitt Cancer Center.

⁹UT Southwestern Simmons Comprehensive Cancer Center.

¹⁰Johns Hopkins Kimmel Cancer Center.

¹¹Roswell Park Comprehensive Cancer Center.

¹²Mayo Clinic Comprehensive Cancer Center.

¹³Fox Chase Cancer Center.

¹⁴Huntsman Cancer Institute at the University of Utah.

¹⁵Fred Hutchinson Cancer Center.

¹⁶Abramson Cancer Center at the University of Pennsylvania.

¹⁷City of Hope National Medical Center.

¹⁸Fred & Pamela Buffett Cancer Center.

¹⁹Indiana University Melvin and Bren Simon Comprehensive Cancer Center.

²⁰Memorial Sloan Kettering Cancer Center.

²¹UC Davis Comprehensive Cancer Center.

²²UCLA Jonsson Comprehensive Cancer Center.

²³Dana-Farber Cancer Institute.

²⁴The UChicago Medicine Comprehensive Cancer Center.

²⁵University of Colorado Cancer Center.

²⁶O’Neal Comprehensive Cancer Center at UAB.

²⁷Independent Patient Advocate.

²⁸The University of Texas MD Anderson Cancer Center.

²⁹The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute.

³⁰UCSF Helen Diller Family Comprehensive Cancer Center.

³¹UC San Diego Moores Cancer Center.

³²University of Wisconsin Carbone Cancer Center.

³³The University of Tennessee Health Science Center.

³⁴National Comprehensive Cancer Network.