Influence
September 17, 2024

Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia During Pregnancy: US Preventive Services Task Force Recommendation Statement

Sarah Wiehe, MD

Published in JAMA. Here is a link to the article.

Regenstrief Institute authors: Sarah Wiehe, M.D., MPH

Abstract

Importance: Iron deficiency is the leading cause of anemia during pregnancy. According to survey data from 1999 to 2006, overall estimated prevalence of iron deficiency during pregnancy is near 18% and increases across the 3 trimesters of pregnancy (from 6.9% to 14.3% to 28.4%). An estimated 5% of pregnant persons have iron deficiency anemia.

Objective: The US Preventive Services Task Force (USPSTF) commissioned a systematic review to evaluate the evidence on the benefits and harms of screening and supplementation for iron deficiency with and without anemia on maternal and infant health outcomes in asymptomatic pregnant persons.

Population: Asymptomatic pregnant adolescents and adults.

Evidence assessment: The USPSTF concludes that the current evidence is insufficient, and the balance of benefits and harms of screening for iron deficiency and iron deficiency anemia in asymptomatic pregnant persons on maternal and infant health outcomes cannot be determined. The USPSTF also concludes that the current evidence is insufficient, and the balance of benefits and harms of iron supplementation in asymptomatic pregnant persons on maternal and infant health outcomes cannot be determined.

Recommendation: The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for iron deficiency and iron deficiency anemia in pregnant persons to prevent adverse maternal and infant health outcomes. (I statement) The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of routine supplementation for iron deficiency and iron deficiency anemia in pregnant persons to prevent adverse maternal and infant health outcomes. (I statement).

Authors: 

US Preventive Services Task ForceWanda K Nicholson 1Michael Silverstein 2John B Wong 3David Chelmow 4Tumaini Rucker Coker 5Esa M Davis 6Carlos Roberto Jaén 7Marie Krousel-Wood 8Sei Lee 9Li Li 10Goutham Rao 11John M Ruiz 12James Stevermer 13Joel Tsevat 7Sandra Millon Underwood 14Sarah Wiehe 15

Affiliations: 

1George Washington University, Washington, DC.

2Brown University, Providence, Rhode Island.

3Tufts University School of Medicine, Boston, Massachusetts.

4Virginia Commonwealth University, Richmond.

5University of Washington, Seattle.

6University of Maryland School of Medicine, Baltimore.

7University of Texas Health Science Center, San Antonio.

8Tulane University, New Orleans, Louisiana.

9University of California, San Francisco.

10University of Virginia, Charlottesville.

11Case Western Reserve University, Cleveland, Ohio.

12University of Arizona, Tucson.

13University of Missouri, Columbia.

14University of Wisconsin, Milwaukee.

15Indiana University, Bloomington.

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