Paul I. Musey, M.D., M.S., FACEP

Contact : pmusey@iu.edu

Emergency care research must include actively engaged stakeholders, particularly patients, whose invaluable insights and experiences can shape care strategies that truly meet community needs.

Initiatives

Care Delivery

Research Scientist, William M. Tierney Center for Health Services Research, Regenstrief Institute
Eskenazi Health Foundation Chair and Scholar of Emergency Medicine
Medical Director, IU Health Enterprise Clinical Research Operations (ECRO)
Associate Professor of Emergency Medicine, IU School of Medicine
Vice Chair of Research & Innovation, IU School of Medicine

Dr. Paul Musey is the Eskenazi Health Foundation Scholar of Emergency Medicine and Vice Chair of Research and Innovation for the Indiana Unversity School of Medicine (IUSM) Department of Emergency Medicine. He is originally from Atlanta, Georgia and received his B.S. in Chemistry from Georgia State University in 2005 before graduating from Emory University School of Medicine in 2009. He subsequently completed an Emergency Medicine residency at Carolinas Medical Center in Charlotte, North Carolina in 2012 and stayed on there as faculty until he took a faculty position at IUSM in 2014. At IUSM he went on to complete an Emergency Medicine research fellowship and earned a Masters in Clinical Research.

Dr. Musey’s clinical research interests surround the evaluation and management of psychological contributors to ED presentations. Specifically, he has built a research program focused on the evaluation and management of how underlying mental health conditions (anxiety, depression or PTSD) affect the trajectory of emergency department (ED) care, patient-centered outcomes and healthcare resource utilization. Additional interests include the evaluation and elimination of health disparities in emergency care. He has developed expertise in patient engagement and partnerships in the evaluation of evidence-based treatment options. He has been PI or site PI for a number of ED clinical studies in this area and has received funding from the Emergency Medicine Foundation, the Society for Academic Emergency Medicine Foundation, NIH, and most recently from the Patient Centered Outcomes Research Institute (PCORI). He currently holds a leadership position in the Indiana University Health System as Medical Director for IU Health’s Enterprise Clinical Research Organization (ECRO) where he works to shape the vision for supporting high-impact clinical trials across the health system with a special focus on the Cardiovascular and Neurosciences Institutes.

Featured Projects

Patient-Centered Treatment of Anxiety after Low-Risk Chest Pain in the Emergency Room Agency

PCORI (Patient-Centered Outcomes Research Institute
Agency)

Role: Contact PI

Prospective randomized comparative effectiveness trial evaluating the additive benefit of anxiety screening, brief intervention and referral to treatment (SBIRT) + either online cognitive behavioral therapy (CBT) + group-based peer support vs telehealth delivered CBT in low risk chest pain patients presenting to the ED.

Automated EMR-integrated mental health screening assessments in the ED

(IU Health Values Fund – pilot and feasibility studies)

(PI: Nevel)

This study aims to leverage Electronic Medical Record (EMR)-integrated MH assessment tools with an automated digital patient engagement platform (Twistle) to accomplish two objectives: 1) Deliver automated HIPAA-compliant MH screening assessments (GAD-7/PHQ-9) directly to the mobile device of ED patients presenting with non-psychiatric (somatic) complaints and 2) Automate the post-visit connection of positively-screened patients to appropriate avenues of care.

Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance with Sublingual Cyclobenzaprine HCl (TNX-102 SL) – (Optimizing Acute Stress reaction Interventions with TNX-102 SL – OASIS)

(DOD – UNC)

Role: Site Principal Investigator (PI: McLean – UNC)

Clinical trial in partnership with Tonix Pharmaceuticals in which we would administer Cylcobenzaprine, an oral tablet that can be safely administered acutely and during the post-acute phase (14 days) for rapid prevention of ASRs and PTSD after a traumatic event.

Enhancing U.S. Surveillance of Laboratory Confirmed SARS-CoV-2, Influenza and other respiratory Viruses through a Network of Emergency Departments

(CDC – Wayne State University)

Role: Co-Investigator (PI: Kline – Wayne State)

This surveillance system provides timely data on the primary viruses causing ARI and how each virus’s activity might vary over time and by age group. The percent positivity metric can be used to follow trends and comparisons of laboratory confirmed SARS-CoV-2, influenza, and RSV activity in different age groups and geographic areas (HHS Regions) of the United States.

ICECAP: Influence of Cooling duration on Efficacy in Cardiac Arrest Patients Trial

(U. Michigan-Ann Arbor/NIH-NHLBI 1UG3HL145269-01A1) (Meurer)

Role: Site PI

This clinical trial proposes to first determine whether longer durations of cooling improve recovery better than shorter durations, and secondly to determine the best duration of cooling, in comatose patients resuscitated from either of two different types of cardiac arrest.

Early Phase Pain Investigation Clinical Network MACC/EPPIC-Net as a Hub for the HEAL Initiative

(NIH – Medical College of Wisconsin RFA-NS-19-036)

Role: Site Principal Investigator (PI: Aufderheide)

EPPIC-Net will provide a robust and readily accessible infrastructure for carrying out in-depth phenotyping and biomarker studies in patients with specific pain conditions, and the rapid design and performance of high-quality Phase 2 clinical trials to test promising novel therapeutics for pain from partners in academia or industry.

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Paul I. Musey, M.D., M.S., FACEP

Featured Projects