Paul R. Dexter, MD

Contact : prdexter@regenstrief.org

Precision health will soon exceed human cognitive capacity by orders of magnitude, ensuring that health care’s future is entwined with computers and software.

Initiatives

Research Scientist, Clem McDonald Center for Biomedical Informatics, Regenstrief Institute
Associate Professor of Clinical Medicine, Indiana University School of Medicine

Dr. Dexter has been a Biomedical Informatics research scientist at the Regenstrief Institute for more than 25 years, helping to shape Regenstrief’s information systems for both clinical and research purposes. He served as the Chief Medical Information Officer (CMIO) of Eskenazi Health (formerly Wishard Health Services) for 12 years and IU’s interim and Clinical Research Information Officer (CRIO) for two years. He has coordinated and published a number of randomized clinical decision support trials, including in the New England Journal of Medicine, JAMA, and Annals of Internal Medicine. As principal investigator of an AHRQ grant, Dr. Dexter spearheaded the implementation of a new clinical decision support platform, natural language processing, i2b2 de-identified query, and other research informatics capacity within Regenstrief Institute. More recently, he served as Indiana’s co-principal investigator of NIH’s Implementing Genomics in Practice (IGNITE) consortium, which is conducting multiple genomics studies. Dr. Dexter is also the Regenstrief faculty lead for the Merck-Regenstrief collaborative, as well as coordinating with Eskenazi Health leadership on a pilot study using deidentified EHR data to monitor for racial and ethnic disparities.

Featured Projects

The Big Ten Electronic Health Record Consortium (Big Ten-EHRC)

(NIH/NCI)

Role: Co-Investigator

Goal: To create a consortium of Cancer Centers that will communicate and coordinate with the NCI and with EHR vendors to facilitate and harmonize rapid implementation of EHR investigative treatment plans for the conduct of NCTN clinical trials.

Implementing Genomic Medicine through Pragmatic Trials in Diverse and Underserved Populations across Indiana

(NIH-NHGRI)

Role: Co-principal investigator for Indiana

Goal: To build research infrastructure to recruit for multiple genomics studies related to hypertension, acute and chronic pain, and depression.

Merck Master Collaborative Agreement

(Merck, Sharp & Dohme Corp.)

Role: Principal Investigator

Merck Exploratory Studies Project and project related to constructing a breast cancer repository

Dr. Dexter serves as the lead faculty member for the collaborative agreement with various clinical researchers leading individual projects. The individual projects he leads focus on data analysis and phenotyping for data pulls.

Regenstrief health equities and disparities pilot research project

To construct pragmatic methods to monitor for institutional disparities that would warrant further exploration.

Highlighted Publications

2021

Golden opportunities for clinical decision support in an era of team-based healthcare

Publication: AMIA Annual Symposium Proceedings

Authors: Dexter P, Schleyer T

2019

Development of a Genomic Data Flow Framework: Results of a Survey Administered to NIH-NHGRI IGNITE and eMERGE Consortia Participants

Publication: AMIA Annual Symposium Proceedings

Authors: Dexter P, Ong H, Elsey A, Bell G, Walton N, Chung W, Rasmussen L, Hicks K, Owusu-obeng A, Scott S, Ellis S., Peterson, J

2021 Jan 25

Transforming primary medical research knowledge into clinical decision

Publication: AMIA Annual Symposium Proceedings

Authors: Dexter PR, Grout RW, Embi PJ

2021 Oct 12

An Automated Line-of-Therapy Algorithm for Adults With Metastatic Non-Small Cell Lung Cancer: Validation Study Using Blinded Manual Chart Review

Publication: JMIR Medical Informatics

doi: 10.2196/29017

Authors: Meng W, Mosesso KM, Lane KA, Roberts AR, Griffith A, Ou W, Dexter PR

Projects

Pharmacogenomics

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In The News

Influence

Featured Fellowship

People

NewsDementia risk prediction: Zero-minute assessment at less than a dollar cost

NewsRegenstrief Institute researcher appointed associate dean for research at IU Indianapolis Fairbanks School of Public Health

InfluenceAlzheimer Disease as a Clinical-Biological Construct-An International Working Group Recommendation

InfluenceAMIA honors Regenstrief researcher with leadership award

VideoDr. Weiner: Patients and doctors can collaborate to improve medical records

Dementia risk prediction: Zero-minute assessment at less...

Paul R. Dexter, MD

Featured Projects

Highlighted Publications

Projects